Many people try to diagnose themselves visually. In fact, “herpes photos” is the third most popular phrase typed into search engines. “herpes” and “genital herpes” are the only phrases searched for more often.
Unfortunately, it is difficult to correctly diagnose genital herpes by visual inspection alone. This is difficult because the symptoms can be very mild and because many other conditions look like genital herpes. Other conditions which can look like genital herpes include:
Just how difficult is it to visually diagnose genital herpes? There was a study in the New England Journal Of Medicine where doctors were asked to diagnose genital herpes by visual inspection alone. A laboratory test was then performed to check the doctor’s visual diagnosis. One out of five doctors was wrong. If a highly trained medical professional only gets it right 80% of the time then the chances that you can diagnose yourself by looking at some online photos are not very good at all.
It makes a huge difference which laboratory test you choose. Some tests are nearly 100% accurate. Some tests are strongly not recommended because they can confuse genital herpes with the common cold sore. That’s right. Some of the tests out there can’t even tell the difference between genital herpes and a cold sore. Imagine how you would feel if you were told you had genital herpes when what you really had was the very common cold sore. It is important to know how to choose the right test.
The most common way to test for herpes directly is through a viral culture. If you get a positive result from a viral culture then you can be very confident (>95%) that you have genital herpes. Unfortunately a negative result from a viral culture is not as reliable. If you are able to sample the sores when they are active then the viral culture is very accurate but this is not always possible. Sometimes the sores have started to heal and sometimes the viruses die on the way to the lab. It is a good idea to confirm a direct test with a blood antibody test.
All of the blood antibody tests listed below are very accurate (above 90%). One key factor which can influence your results is the amount of time you have been infected. Blood antibodies are produced by your body after weeks or months so if you have recently been infected then the blood antibody test may not detect anything.
These tests are covered under most insurance plans. The only cost would be the co-pay charge. For those with no health insurance the cost will range from $100.00 to $200.00 depending on the type of test you choose.
You can use a combination of direct and indirect tests to learn if your infection was recently acquired. If you are suffering from your first outbreak you can request both a direct test (viral culture or PCR) and an indirect test (blood antibody test).
It will take your body anywhere from a couple of weeks to several months to begin producing antibodies against the herpes virus. If your viral culture comes back positive but your blood antibody test comes back negative this means that the virus was found but antibodies were not found. Your infection was most likely acquired very recently.
This is only possible if this is your first outbreak. If you have had more than one outbreak then it is no longer possible to determine when you acquired the virus.
Every part of dealing with genital herpes is uncomfortable and potentially humiliating or embarrassing. Even calling a local clinic to make an appointment can be intimidating. A good way to do this is to avoid using the words “genital herpes”. Instead you could ask the following: “Hi. I need to schedule an appointment for an HSV blood test. Also, I would prefer an IgG type specific test.” Just using different words makes a huge difference. The important thing is to get tested.
There are really only two choices when it comes to direct testing. Remember that direct testing means testing for the presence of the herpes virus whereas indirect testing checks for the presence of blood antibodies. Direct tests either detect the presence of the herpes virus or they don’t.
Viral Culture Or Cell Culture | Viral DNA Testing (PCR*) | |
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How They Work | These tests work by growing more copies of the virus in a cell culture and then looking for changes under a microscope | These tests work by making lots of copies of the herpes virus DNA so that even very small numbers of the virus can be detected |
Tissue Sampled |
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Disadvantages |
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*PCR stands for Polymerase Chain Reaction which is a scientific technique in molecular biology used to amplify a single or a few copies of a piece of DNA across several orders of magnitude, generating thousands to millions of copies of a particular DNA sequence.
Pap smears and Tsank tests are not recommended for direct testing due to a lack of accuracy. And don’t even think about letting a doctor visually diagnose you with genital herpes.
IgM and IgG refer to different kinds of blood antibodies which your body produces to fight the herpes virus. IgM antibodies start to appear within a few days from exposure to the virus, reach a peak level within two to four weeks and slowly disappear within two to three months. IgM antibodies are not type specific meaning there is no way to know whether the antibodies come from HSV-1 or HSV-2. This is why an IgM test alone is not a good idea since by itself it will not tell you if you have HSV-1 or HSV-2. IgG antibodies on the other hand are type specific. They can be used to determine which type of herpes virus you have. They may appear within three to four weeks and are definitely present four to six months after exposure.
The table lists many IgG specific blood antibody tests. All of these tests are accurate, FDA approved, and relatively inexpensive. There have been many new tests introduced recently – you can see that four of the tests listed below were FDA approved within the last three years.
Antibodies Detected |
Result Time |
FDA Approved |
More Information | Comments | |
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Biokit HSV-2 Rapid Test |
Only HSV-2 | 10 minutes | 1999 |
800-926-3353 |
This is the same test as the Fisher Sure-Vue HSV-2 Rapid Test |
BioPlex HSV | HSV-1 & HSV-2 | 1 week | 2009 |
800-224-6723 |
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Captia ELISA | HSV-1 & HSV-2 | 1 week | 2004 |
888-291-0415 |
They offer both IgM and IgG tests – be sure to specify the IgG test |
Euroimmun Anti HSV-1 & Anti HSV-2 ELISA |
HSV-1 & HSV-2 | 1 week | 2007 |
800-913-2022 |
They offer both IgM and IgG tests – be sure to specify the IgG test |
HerpeSelect HSV-1 & HSV-2 ELISA |
HSV-1 & HSV-2 | 1 week | 2002 |
800-838-4548 |
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HerpeSelect 1 & 2 Differentiation Immunoblot | HSV-1 & HSV-2 | 1 week | 2000 |
800-838-4548 |
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Liaison HSV-2 | HSV-1 & HSV-2 | 1 week | 2008 |
800-328-1482 |
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Western Blot | HSV-1 & HSV-2 | 2 – 3 weeks | N/A |
800-713-5198 |
This is the most accurate test currently available and is the test which all other tests are compared to |
AtheNA MultiLyte | HSV-1 & HSV-2 | 1 week | 2008 |
800-257-9525 |
They offer both IgM and IgG tests – be sure to specify the IgG test |
So now that you have your test results back what do they mean? Your blood antibody test can return three results: negative, positive, or equivocal. You may also be given a number called the index, cut-off index, or antibody index. A negative result is an index significantly less than 1. A positive result is an index significantly greater than 1. An equivocal result is an index value between 0.9 and 1.1.
Test Result | Interpretation |
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< 0.9 | Negative: No significant level of detectable IgG antibody to HSV. |
0.9 – 1.1 | Equivocal: Questionable presence of IgG antibody to HSV. Repeat testing or alternative testing may be helpful. |
> 1.1 | Positive: IgG antibody to HSV detected. This may indicate a current or recent HSV infection. |
If you receive an equivocal result you will probably be encouraged to repeat the test after a few weeks. You will also be encouraged to retest if the viral culture and antibody tests give conflicting results.
Feel free to look around the other sections of this website for information on topics such as preventing the Transmission Of Herpes, finding Herpes Support Groups, and How To Tell Someone You Have Herpes. Also, be sure and check out the Herpes Dating eBook. It is the best available resource on the subject. You will find lots of great information inside including the following:
Dating With Herpes eBook • Telling Someone You Have Herpes
Transmission Of Herpes • Herpes Dating Sites • Herpes Forum
How Do I Know If I Have Herpes • Genital Herpes FAQ